Dornase Alfa for Severe Trauma Patients in ICU

We are studying whether inhaled dornase alfa can help reduce serious lung complications in ventilated patients with severe trauma. This trial aims to see if it lowers the risk of ARDS and improves recovery outcomes.

Confirmation phase (III)Standard MedicinesInternal MedicinePulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Pulmozyme
Pulmozyme is a medicine inhaled into the lungs to help thin and clear mucus in people with cystic fibrosis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dornase Alfa
Dornase alfa is a substance that thins and clears thick lung mucus by breaking down DNA, helping people with cystic fibrosis breathe easier.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Pulmozyme Inhalasjonsvæske Til Nebulisator, Oppløsning
Pulmozyme Otopina Za Atomizator
Pulmozyme Purškiamasis Įkvepiamasis

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire D'Angers
49
Angers, France
University Hospital Of Clermont-Ferrand
63
Beaumont, France
Centre Hospitalier Universitaire De Toulouse
31
Blagnac, France
Sponsor: Les Hopitaux Universitaires De Strasbourg
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.