Dostarlimab for Advanced Cancer with dMMR/MSI

We are studying whether the immunotherapy dostarlimab can help patients with advanced non-colorectal and non-endometrial cancers live longer compared to standard treatments. This trial focuses on those with specific genetic markers in their tumors.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate helps protect the body from side effects of some chemotherapy drugs and restores folate (vitamin B9) levels.
Capecitabine
Capecitabine is a chemotherapy medicine used to treat certain cancers, including breast and colon cancer.
Carboplatin
Carboplatin is a chemotherapy medicine used to treat various types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Capecitabine
Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.
Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax
Antrex
Apexelsin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut De Cancerologie De L Ouest
Oncologie
Angers, France
Institut Sainte Catherine
Oncologie Médicale
Avignon, France
Centre Jean Perrin
Oncologie digestive
Beaumont, France

Sponsor: Unicancer
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.