Early-Stage Colon Cancer: NICHE Trial for Immunotherapy

We are studying a new immunotherapy treatment for patients with early-stage colon cancer to see if it can reduce tumors before surgery. The trial also aims to identify biomarkers that may help tailor treatments and improve patient outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Celebrex
Celebrex is a medicine used to relieve pain and inflammation from arthritis and other painful conditions.
Celecoxib
Celecoxib is a medicine used to reduce pain and swelling from arthritis and other short-term painful conditions.
Opdivo
Opdivo is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Celecoxib
Celecoxib is a substance that reduces pain and inflammation, commonly used to treat arthritis and other inflammatory conditions.
Eltrombopag
Eltrombopag is a substance that increases platelet production to help manage low platelet counts.
Ipilimumab
Ipilimumab is a substance that helps the immune system attack cancer by blocking a protein that keeps immune cells from working.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Anti-Il8 Mab

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aclexa
Aclexa
Algoxib

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Flevoziekenhuis Stichting
Surgery
Almere Stad, Netherlands
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Gastroenterology
Amstelveen, Netherlands
Stichting OLVG
Gastroenterology
Amsterdam, Netherlands

Sponsor: Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.