Ectopic Pregnancy: Mifepristone and Letrozole vs. Methotrexate

We are studying whether a new combination treatment is as effective as the standard medication for ectopic pregnancy. This trial will also look at side effects and the need for further medical interventions.

>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOralInjectionGynecology and Obstetrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Letrozole
Letrozole is a medicine used to treat certain breast cancers in women after menopause by lowering hormones that can fuel tumor growth.
Letrozole Sandoz
Letrozole Sandoz is a medicine used to treat certain types of breast cancer in women after menopause.
Methotrexate Teva
Methotrexate Teva is a medicine used to treat certain cancers and immune system conditions such as rheumatoid arthritis and psoriasis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Letrozole
Letrozole is a substance that lowers estrogen to treat certain types of breast cancer in postmenopausal women.
Methotrexate
Methotrexate is a substance that slows rapid cell growth and calms the immune system to treat certain cancers and autoimmune conditions.
Methotrexate Sodium
Methotrexate sodium is a substance that slows cell growth and is used to treat certain cancers and autoimmune conditions like rheumatoid arthritis.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aletro
Aletro
Allenda

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Sahlgrenska University Hospital-Vastra Gotalandsregionen
Obstetrics and Gynecology
Göteborg, Sweden
Karolinska University Hospital
Obstetrics and Gynecology
Huddinge, Sweden
Region Oerebro Laen
Institutionen för medicinsk vetenskap, kvinnokliniken
Örebro, Sweden
Sponsor: Karolinska Institutet
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.