Endometrial Cancer: Durvalumab with Chemotherapy

We are studying a new treatment combining durvalumab with standard chemotherapy for patients with advanced or recurrent endometrial cancer. The goal is to see if this approach improves survival and quality of life compared to chemotherapy alone.

>2 years Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Partially Remote Standard Medicines Oral InjectionGynecology and ObstetricsOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Flixabi

Flixabi is a medicine used to reduce inflammation in autoimmune conditions like rheumatoid arthritis, Crohn's disease, and psoriasis.

Imfinzi

Imfinzi is a cancer medicine that helps the immune system find and fight tumor cells.

Lynparza

Lynparza is a cancer medicine used to treat certain ovarian, breast, pancreatic, and prostate cancers, especially those caused by specific gene changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Durvalumab

Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.

Infliximab

Infliximab is a substance that reduces inflammation by blocking a protein called TNF and is used for autoimmune conditions like rheumatoid arthritis and Crohn's.

Mycophenolate Mofetil

Mycophenolate mofetil is a substance that suppresses the immune system to prevent organ transplant rejection and treat autoimmune conditions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cellcept

Inflectra

Micofenolat Mofetil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jessa Ziekenhuis

Medical Oncology

Hasselt, Belgium

UZ Leuven

Medical Oncology

Heverlee, Belgium

Algemeen Ziekenhuis Groeninge

Medical Oncology

Kortrijk, Belgium

Sponsor: AstraZeneca AB

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.