Endometrial Cancer: New Treatment Combinations

We are studying whether a new combination of Trastuzumab Deruxtecan with Rilvegostomig or Pembrolizumab is more effective than standard chemotherapy for patients with advanced or recurrent HER2-expressing endometrial cancer.

Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Partially Remote Investigational Medicines Oral InjectionGynecology and ObstetricsOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carboplatin

Carboplatin is a chemotherapy medicine used to treat various types of cancer.

Paclitaxel

Paclitaxel is a chemotherapy medicine used to treat various types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carboplatin

Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.

Docetaxel

Docetaxel is a chemotherapy substance used to treat various cancers by stopping cancer cells from dividing.

Infliximab

Infliximab is a substance that reduces inflammation by blocking a protein called TNF and is used for autoimmune conditions like rheumatoid arthritis and Crohn's.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Rilvegostomig

Ds-8201a

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax

Apexelsin

Axitaxel

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck

University clinic for Gynaecology

Innsbruck, Austria

Kepler Universitaetsklinikum GmbH

Department of Gynaecology, Obstetrics and Gyn. Endocrinology

Linz, Austria

Klinik Hietzing

Karl Landsteiner Institute for Gynecology and Senology, Department of Gynecology and Obstetrics

Perchtoldsdorf, Austria

Sponsor: AstraZeneca AB

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.