Endometrial Cancer: Sacituzumab Tirumotecan and Pembrolizumab Study

We are studying a combination of sacituzumab tirumotecan and pembrolizumab for people with advanced or recurrent endometrial cancer. The goal is to see if this combination works better than pembrolizumab alone.

Confirmation phase (III)Cost ReimbursementPartially RemoteInvestigational MedicinesInjectionInternal MedicineOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy medicine used to treat various types of cancer.
Cimetidine Cf
Cimetidine Cf is a medicine that reduces stomach acid to treat ulcers, heartburn, and acid reflux.
Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Buclizine Hydrochloride
Buclizine hydrochloride is an antihistamine substance used to prevent nausea, vomiting, and motion sickness.
Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.
Cimetidine
Cimetidine is a substance that reduces stomach acid to relieve heartburn and treat ulcers.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mk-2870

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

4-In-One Flu Relief
6 Years Plus Paracetamol Boots
Abacat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Medical University Of Graz
Universitätsklinik für Frauenheilkunde und Geburtshilfe
Graz, Austria
Medizinische Universitaet Innsbruck
Universitätsklinik für Gynäkologie und Geburtshilfe
Innsbruck, Austria
Medical University Of Vienna
Universitätsklinik für Frauenheilkunde
Vienna, Austria
Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.