Eplontersen for Transthyretin-Mediated Amyloid Cardiomyopathy

We are studying the long-term safety of eplontersen in adults with ATTR-CM. This trial will help us understand how well the treatment is tolerated over an extended period.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Concavit
Vitaminum A Hasco
Vitaminum A Hasco is a vitamin A supplement used to prevent or treat vitamin A deficiency and support vision and immune health.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

All-Rac-Alpha-Tocopheryl Acetate Bp
All-rac-alpha-tocopheryl acetate BP is a form of vitamin E used as an antioxidant and to prevent or treat vitamin E deficiency.
Ascorbic Acid Bp
Ascorbic acid BP is vitamin C that helps prevent or treat deficiency and supports immune function and wound healing.
Calcium Pantothenate Bp
Calcium pantothenate is a form of vitamin B5 used to prevent or treat deficiency and support energy production and skin health.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ion 682884

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aksoderm
Aksoderm Forte
Auxina A Masiva

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Department of Cardiology
Graz, Austria
Medizinische Universitaet Innsbruck
Universitätsklinik für Innere Medizin III - Kardiologie und Angiologie
Innsbruck, Austria
Medical University Of Vienna
Clinical Department for Cardiology
Vienna, Austria

Sponsor: Ionis Pharmaceuticals Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.