Esophageal Adenocarcinoma: The PRESTO Trial

We are studying a combination of durvalumab and chemoradiation to see if it can help preserve the esophagus in patients with early-stage cancer. This trial aims to avoid surgery and assess treatment effectiveness and safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Imfinzi
Imfinzi is a cancer medicine that helps the immune system find and fight tumor cells.
Leucovorin
Leucovorin is a medicine used with chemotherapy to reduce harmful side effects and help cancer treatments work better.
Medoxa

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Calcium Folinate Pentahydrate
Calcium folinate pentahydrate is a form of folate used to treat folate deficiency and lessen side effects of certain chemotherapy.
Calcium Levofolinate
Calcium levofolinate is a substance that helps protect healthy cells during some cancer treatments and restores folate levels.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Antrex
Bendadocel
Buateron

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Klinikum St Marien Amberg
Onkologisches Zentrum
Amberg, Germany
Charite Universitaetsmedizin Berlin KöR
Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie
Berlin, Germany
St. Josef-Hospital
Hämatologie und Onkologie mit Palliativmedizin
Bochum, Germany

Sponsor: Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbH
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.