Esophageal Cancer Treatment: The NEEDS Trial

We are comparing two treatment methods for operable esophageal squamous cell carcinoma to see which may help patients survive longer. The study also examines quality of life and other health impacts during and after treatment.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Calcium Folinate Sandoz
Calcium Folinate Sandoz is a medicine used to protect healthy cells during some chemotherapies and to treat low folate levels.
Carboplatin Accord
Carboplatin Accord is a chemotherapy medicine used to treat several types of cancer.
Cisplatin Accord
Cisplatin Accord is a chemotherapy medicine used to treat various types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate Pentahydrate
Calcium folinate pentahydrate is a form of folate used to treat folate deficiency and lessen side effects of certain chemotherapy.
Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.
Cisplatin
Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Oxaliplatin

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

5-Fluorouracil
5-Fluorouracil Ebewe
5-Fluorouracil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Sainte Catherine Institut Du Cancer Avignon-Provence
Radiation Oncology
Avignon, France
Hopital Ambroise Pare
Chirurgie Générale Digestive et Ontologique
Boulogne-Billancourt, France
Centre Francois Baclesse
Medical Oncology
Caen, France

Sponsor: Karolinska University Hospital
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.