Ewing Sarcoma: Dinutuximab Beta with Chemotherapy

We are studying a new treatment combining dinutuximab beta with standard chemotherapy for patients with GD2-positive Ewing sarcoma. The goal is to find the best dose and assess how well it works in improving patient outcomes.

>2 yearsSafety phase (I)No PlaceboStandard MedicinesInjectionOncologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Etoposide
Etoposide is a chemotherapy medicine used to treat various types of cancer.
Filgrastim Hexal
Filgrastim Hexal is a medicine that boosts white blood cell production to help reduce infection risk during chemotherapy or after bone marrow transplant.
Mesna Eg
Mesna Eg is a medicine used to protect the bladder from damage caused by certain chemotherapy drugs.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Dinutuximab Beta
Dinutuximab beta is an antibody that helps the immune system attack high-risk neuroblastoma, a type of childhood cancer.
Doxorubicin
Doxorubicin is a chemotherapy substance used to treat various cancers by killing rapidly dividing cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accofil
Celltop
Ebeposid

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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St. Anna Kinderspital GmbH
Pediatric oncology
Vienna, Austria
Fakultni Nemocnice V Motole
Pediatric Hematology and Oncology
Stodůlky, Czechia
HELIOS Kliniken GmbH
Klinik für Kinder- und Jugendmedizin
Bernau bei Berlin, Germany
Sponsor: GPOH gGmbH
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.