Familial Mediterranean Fever: On-Demand Anakinra Treatment

We are studying whether on-demand Anakinra can help patients with colchicine-resistant FMF manage painful attacks without daily therapy. This trial compares its effectiveness to standard pain management options.

>2 years ≤5 visits Confirmation phase (III)No Placebo Partially Remote Standard Medicines Oral InjectionHematologyInfectious DiseasesInternal MedicineRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Colchicine Opocalcium

Colchicine Opocalcium is a medicine used to treat and prevent gout attacks.

Kineret

Kineret is a medicine that reduces inflammation to treat rheumatoid arthritis and some rare inflammatory conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anakinra

Anakinra is a substance that blocks interleukin-1 to reduce inflammation in conditions such as rheumatoid arthritis and other inflammatory disorders.

Colchicine

Colchicine is a substance that reduces inflammation to treat and prevent gout attacks.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Colcamedin

Colcamexx

Colchanova

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Hopital Tenon

Internal Medicine

Bagnolet, France

Centre Hospitalier Universitaire De Bordeaux

Rheumatology Department

Bordeaux, France

Hospices Civils De Lyon

Paediatrician / rheumatologist

Bron, France

Sponsor: Assistance Publique Hopitaux De Paris

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.