Follicular Lymphoma: Odronextamab vs. Rituximab

We are studying whether odronextamab combined with lenalidomide is safer and more effective than rituximab combined with lenalidomide for adults with relapsed or refractory follicular lymphoma and marginal zone lymphoma.

6-12 months 11-15 visits Confirmation phase (III)No Placebo Partially Remote Standard Medicines Oral InjectionHematologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Lenalidomide

Lenalidomide is a medicine used to treat certain blood cancers and bone marrow disorders, including multiple myeloma.

Truxima

Truxima is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting and reducing harmful immune cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Lenalidomide

Lenalidomide is a substance that helps treat certain blood cancers by affecting the immune system to stop cancer growth.

Odronextamab

Odronextamab is a lab-made antibody that directs immune T cells to attack B-cell non-Hodgkin lymphomas.

Rituximab

Rituximab is a substance that targets and reduces B cells, a type of white blood cell, to treat some blood cancers and autoimmune conditions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

7,5 Mg Stada

Blitzima

Cortedal

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Kepler Universitaetsklinikum GmbH

Univ.-Klinik für Hämatologie und Internistische Onkologie

Linz, Austria

Ordensklinikum Linz GmbH

Internal Medicine

Linz, Austria

Medical University Of Vienna

Department of Medicine I Division of Hematology and Hemostaseology

Vienna, Austria

Sponsor: Regeneron Pharmaceuticals Inc.

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.