Follicular Lymphoma: Tazemetostat with Lenalidomide and Rituximab

We are studying the safety and effectiveness of tazemetostat combined with lenalidomide and rituximab in adults with relapsed or refractory follicular lymphoma. This trial compares the new treatment to a placebo to see how well it works.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Lenalidomide Mylan
Lenalidomide Mylan is a medicine used to treat certain blood cancers, such as multiple myeloma, and some bone marrow disorders.
Lenalidomide Ratiopharm
Lenalidomide Ratiopharm is a cancer medicine used to treat multiple myeloma and some types of blood cancer.
Mabthera
Mabthera is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting problematic immune cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Lenalidomide
Lenalidomide is a substance that helps treat certain blood cancers by affecting the immune system to stop cancer growth.
Rituximab
Rituximab is a substance that targets and reduces B cells, a type of white blood cell, to treat some blood cancers and autoimmune conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Tazemetostat

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

7,5 Mg Stada
7,5 Mg Stada
7,5 Mg Stada

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitair Ziekenhuis Gent
#4003: Hematologie, t.a.v. Katrien De Grove, Studies Hematologie – Route 1456
Ledeberg, Belgium
Centre Hospitalier Universitaire D'Angers
#5027: Hématologie Clinique
Angers, France
Institut Bergonie
#5004: Pavillon Saint Genès
Bordeaux, France

Sponsor: Epizyme Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.