FORE-PAIN Trial: Pain Relief Options for Trauma

We are studying whether intranasal and intravenous forms of fentanyl and esketamine can effectively relieve acute traumatic pain. The goal is to see if these options are as safe and satisfying as traditional intravenous fentanyl.

Confirmation phase (III)No PlaceboInvestigational MedicinesOralInjectionInternal MedicineOtolaryngologyPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Diclofenacnatrium Aurobindo
Diclofenacnatrium Aurobindo is a medicine used to relieve pain and reduce inflammation from conditions like arthritis, muscle injuries, or sprains.
Fentanyl Hameln
Fentanyl Hameln is a strong painkiller used to treat severe pain in people who need powerful, fast-acting pain relief.
Natriumchlorid 0,9 %
Natriumchlorid 0,9% is a sterile salt solution used to replace fluids, hydrate patients, and deliver medicines into a vein.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Diclofenac Sodium
Diclofenac sodium is a substance that reduces pain and inflammation from arthritis and other muscle or joint problems.
Esketamine
Esketamine is a fast-acting antidepressant substance used to relieve depression symptoms when other treatments haven't worked.
Fentanyl Citrate
Fentanyl citrate is a potent opioid substance used to relieve severe pain, especially during surgery or for cancer-related pain.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Midazolam

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

4-In-One Flu Relief
4-In-One Flu Relief
6 Years Plus Paracetamol Boots

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ambulance Amsterdam
Medical Manager
Amsterdam, Netherlands
Sponsor: Amsterdam UMC
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.