Fronto-Temporal Dementia: LY3884963 Treatment Study

We are testing a new injection for patients with fronto-temporal dementia due to progranulin mutations. The study aims to evaluate its safety and effects on a key protein related to the disease.

>2 years 16-20 visits Safety phase (I)Efficacy phase (II)No Placebo Cost Reimbursement Partially Remote Investigational Medicines Oral InjectionInternal MedicineNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Prednisona Cinfa

Prednisona Cinfa is a steroid medicine used to reduce inflammation and treat allergic reactions, asthma flare-ups, and certain autoimmune conditions.

Prednisone Mylan Pharma

Prednisone Mylan Pharma is a medicine that reduces inflammation and treats allergies, asthma, and autoimmune diseases.

Rapamune

Rapamune is a medicine used to help prevent the body from rejecting a transplanted kidney by lowering the immune system’s activity.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Methylprednisolone

Methylprednisolone is a corticosteroid that reduces inflammation and calms an overactive immune system.

Prednisone

Prednisone is a steroid substance that reduces inflammation and suppresses the immune system for conditions like allergies, asthma, and autoimmune disorders.

Sirolimus

Sirolimus is a substance that suppresses the immune system to help prevent rejection after organ transplantation.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Adeno-associated Viral Vector Serotype 9

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Brucorten

Cison

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven

Neurology

Heverlee, Belgium

Centre Hospitalier Universitaire De Lille

Hopital Roger Salengro Centre Memoire de Ressources et de Recherches

Loos, France

Centre Hospitalier Regional De Marseille

Hopital de la Timone Neurologie et Neuropsychologie Pole de Neurosciences Cliniques

Marseille, France

Sponsor: Prevail Therapeutics Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.