Frontotemporal Dementia
Frontotemporal dementia (FTD) is a rare form of dementia that affects the frontal and temporal lobes of the brain, leading to significant changes in personality, behavior, and language abilities.
Frontotemporal Dementia: DNL593 Study
We are evaluating the safety and tolerability of a new drug, DNL593, in healthy individuals and those with frontotemporal dementia. This study aims to understand how the drug works in the body and its effects over time.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 18 and 80 years old?
- Are you currently pregnant or breastfeeding?
- Do you have any major health problems like heart disease, cancer, or severe mental health issues?
- Have you had a stroke or seizure in the past 5 years?
- Have you ever been diagnosed with a serious neurological condition?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Dnl593
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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UZ Leuven
Neurology
Heverlee, Belgium
Antwerp University Hospital
Neurology
Wilrijk, Belgium
Fakultni Nemocnice V Motole
Neurologická klinika
Stodůlky, Czechia
Sponsor: Denali Therapeutics Inc.
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.