Gastro-Enteropancreatic Neuroendocrine Tumors: RYZ101 Treatment

We are studying a new treatment, RYZ101, for patients with advanced GEP-NETs that have progressed after previous therapy. The trial compares RYZ101 to standard care to see if it improves patient outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Octreotide
Octreotide is a medicine that reduces excess hormone effects, used for conditions like acromegaly and certain hormone-secreting tumors.
Sunitinib
Sunitinib is a cancer medicine used to treat certain kidney cancers and tumors of the digestive tract and pancreas.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Everolimus
Everolimus is a substance that suppresses the immune system to prevent organ rejection and helps slow growth of certain cancers.
L-Arginine Hydrochloride
L-Arginine hydrochloride is a salt form of the amino acid L-arginine used to support blood vessel health and improve blood flow.
L-Lysine Hydrochloride
L-lysine hydrochloride is an essential amino acid supplement used to support protein building, tissue repair, and prevent lysine deficiency.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ryz101
Actinium Oxodotreotide

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Egotux
Klertis
Lusmose

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven
302: Gastro-enterologie
Heverlee, Belgium
Institut Jules Bordet
303: Hematologie
Negenmanneke, Belgium
Algemeen Ziekenhuis Delta
304: Gastrenterology
Rumbeke, Belgium

Sponsor: Rayzebio Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.