Colorectal Cancer
Colorectal cancer is a type of cancer that starts in the colon or rectum, often leading to symptoms like changes in bowel habits, abdominal discomfort, and blood in the stool.
Gastrointestinal Cancers: Patritumab Deruxtecan Study
We are evaluating a new treatment for people with gastrointestinal cancers to see if it is safe and effective. This study aims to understand how well it works compared to existing options.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Hepatocellular Carcinoma
Hepatocellular carcinoma is a primary cancer of the liver, often associated with chronic liver disease, and may cause symptoms like weight loss, loss of appetite, and abdominal swelling.
Biliary Tract Cancer
Biliary tract cancer is a rare type of cancer that affects the bile ducts, leading to symptoms such as jaundice, itching, and abdominal pain.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Do you have unresectable or metastatic colorectal cancer, advanced biliary tract cancer, or hepatocellular carcinoma that cannot be treated with local therapy?
- Have you received any treatment for your cancer in the past?
- Have you fully recovered from any side effects of your previous cancer treatment?
- Do you have severe breathing problems due to lung disease or other respiratory issues?
- Do you have any significant heart or blood vessel problems that are not under control?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Mk-1022
Patritumab Deruxtecan
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Hopital De La Croix-Rousse
Service d'hépatologie et gastroentérologie
Caluire-et-Cuire, France
Assistance Publique Hopitaux De Paris
Liver Cancer and Therapeutic Innovation Unit
Clichy, France
Centre De Lutte Contre Le Cancer Eugene Marquis
Digestive oncology
Rennes, France
Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.