Otoferlin Gene-Mediated Hearing Loss
Otoferlin gene-mediated hearing loss is a rare genetic condition that affects the ability to hear, often resulting in profound hearing loss from birth or early childhood due to mutations in the otoferlin gene.
Gene Therapy for Hearing Loss: AAVAnc80-hOTOF
We are studying a new gene therapy for people with hearing loss due to Otoferlin gene mutations. The trial aims to assess the long-term safety and effectiveness of this treatment.
>2 years≤5 visitsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesInternal MedicineNeurologyOtolaryngology
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Do you have OTOF-mediated hearing loss?
- Are you willing to follow all study requirements and complete the consent process?
- Can you attend all follow-up appointments during the study?
- Are you currently taking any medications that might affect your ability to participate?
- Do you have any health conditions that would prevent you from completing the study?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Aavanc80-hotof
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
Loading map...
Sant Joan De Deu Barcelona Hospital
Pediatric Otorhinolaryngology
Esplugues de Llobregat, Spain
Sponsor: Akouos Inc.
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.