GHB Use Disorder: Baclofen Treatment Study

We are testing whether adding baclofen can help reduce the need for GHB during detox for patients with GHB use disorder. This study aims to improve the detox process for those seeking recovery.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Baclofen Mylan
Baclofen Mylan is a medicine used to relax overly tight muscles and reduce muscle spasms from nerve-related conditions.
Xyrem
Xyrem is a prescription medicine used to treat excessive daytime sleepiness and sudden loss of muscle control in people with narcolepsy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Baclofen
Baclofen is a substance that relaxes stiff muscles and reduces muscle spasms from conditions like multiple sclerosis or spinal cord injury.
Sodium Oxybate
Sodium oxybate is a substance that treats narcolepsy by reducing daytime sleepiness and preventing sudden muscle weakness (cataplexy).

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alcover
Anartex
Arixobat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Stichting Radboud University Medical Center
Pscyhiatry
Nijmegen, Netherlands
Novadic-Kentron
NK Vught, detox, diagnostics and treatment
Vught, Netherlands
Sponsor: Stichting Radboud University Medical Center
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.