Glioblastoma Treatment: Olaptesed Pegol with Radiation

We are studying the safety and effectiveness of olaptesed pegol combined with radiation therapy for patients with newly diagnosed glioblastoma and unmethylated MGMT promoter. This trial also explores how different doses may impact treatment outcomes.

6-12 months 11-15 visits Safety phase (I)Efficacy phase (II)No Placebo Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Avastin

Avastin is a cancer medicine used to slow tumor growth by stopping tumors from getting new blood vessels.

Keytruda

Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

Mvasi

Mvasi is a cancer medicine used to treat several types of tumors by blocking the growth of blood vessels that feed the tumor.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bevacizumab

Bevacizumab is a substance that blocks formation of new blood vessels to treat certain cancers and eye conditions caused by abnormal vessel growth.

Pembrolizumab

Pembrolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-1.

Temozolomide

Temozolomide is a substance used in chemotherapy to treat certain types of brain tumors by slowing cancer cell growth.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Temodal

Nox-A12

Olaptesed Pegol

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abevmy

Advecit

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...

Universitaetsklinikum Bonn AöR

Klinik und Poliklinik für Neurologie

Bonn, Germany

Universitaetsklinikum Essen AöR

Klinik für Neurologie

Essen, Germany

Universitaetsklinikum Leipzig AöR

Klinik für Strahlentherapie und Radioonkologie

Leipzig, Germany

Sponsor: TME Pharma AG

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.