Glioma Treatment Study: Temozolomide and Lomustine

We are testing a combination of chemotherapy and radiotherapy for patients with newly diagnosed grade 2 or 3 glioma. The goal is to see if this approach improves survival compared to standard treatments.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Lomustine
Lomustine is a chemotherapy medicine used to treat certain cancers, especially brain tumors and some types of lymphoma.
Procarbazine Alliance Pharmaceuticals
Procarbazine Alliance Pharmaceuticals is a chemotherapy medicine used to treat certain cancers, including Hodgkin lymphoma and some brain tumors.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Lomustine
Lomustine is a cancer-fighting substance used to treat brain tumors and certain lymphomas by killing cancer cells.
Procarbazine
Procarbazine is a cancer-fighting substance used to treat certain types of cancer by stopping tumor cells from growing and dividing.
Procarbazine Hydrochloride
Procarbazine hydrochloride is a cancer-fighting substance used in chemotherapy to help destroy cancer cells, often for Hodgkin lymphoma and some brain tumors.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cecenu®
Lomustin (Ccnu) Medac
Lomustine Medac

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Charite Universitaetsmedizin Berlin KöR
Klinik für Neurochirurgie
Berlin, Germany
Universitaetsklinikum Bonn AöR
Klinik und Poliklinik für Neurologie
Bonn, Germany
Klinikum Chemnitz gGmbH
Neurochirurgie
Chemnitz, Germany

Sponsor: Universitaetsklinikum Heidelberg AöR
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.