Graft-versus-Host Disease: MC0518 Treatment Study

We are testing a new treatment, MC0518, for adults and adolescents with steroid-refractory acute graft-versus-host disease after stem cell transplantation. The study aims to see if it works better than the best available therapy and how it affects patients' quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anti-T Lymphocyte Immunoglobulin For Human Use
Anti-T lymphocyte immunoglobulin is a preparation of antibodies that reduces activity of immune T cells to prevent or treat organ transplant rejection.
Everolimus
Everolimus is a substance that suppresses the immune system to prevent organ rejection and helps slow growth of certain cancers.
Ex Vivo Expanded Autologous Human Corneal Epithelial Cells Containing Stem Cells
Patient's own corneal cells grown outside the body that contain stem cells are used to restore and repair a damaged corneal surface, improving vision.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mc0518
Mesenchymal Stromal Cells

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire Grenoble Alpes
Laboratoire d Hematologie
La Tronche, France
Centre Hospitalier Universitaire De Lille
Service des Maladies du Sang
Loos, France
Centre Hospitalier Universitaire Amiens Picardie
Service d Hematologie Clinique et Therapie Cellulaire
Milhaud, France

Sponsor: Medac Gesellschaft fuer klinische Spezialprapaerate mbH
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.