GVHD Prevention in Elderly AML/MDS Patients: Thymoglobulin vs. Grafalon

We are comparing two treatments to prevent graft versus host disease in elderly patients with acute myeloid leukemia or myelodysplastic syndrome receiving stem cell transplants. The goal is to find out which treatment leads to better outcomes after transplantation.

>2 years6-10 visitsConfirmation phase (III)No PlaceboInvestigational MedicinesOralInjectionHematology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Thymoglobuline
Thymoglobuline is a medicine used to prevent and treat organ transplant rejection by reducing the body's immune response.
Treosulfan Tillomed
Treosulfan Tillomed is a cancer medicine used to treat certain tumors and to help prepare patients for stem cell transplants.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anti-T Lymphocyte Immunoglobulin For Human Use
Anti-T lymphocyte immunoglobulin is a preparation of antibodies that reduces activity of immune T cells to prevent or treat organ transplant rejection.
Ciclosporin
Ciclosporin is a substance that suppresses the immune system to prevent organ transplant rejection and treat autoimmune conditions.
Fludarabine Phosphate
Fludarabine phosphate is used to treat certain blood cancers, especially chronic lymphocytic leukemia and some lymphomas.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Grafalon

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Grafalon
Grafalon Sct
Ovastat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire D'Angers
Hématologie
Angers, France
Centre Hospitalier Universitaire De Caen Normandie
Hématologie
Caen, France
Centre Hospitalier Universitaire De Bordeaux
Hématologie
Canéjan, France
Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.