H3 K27M-Mutant Diffuse Glioma
H3 K27M-mutant diffuse glioma is a rare and aggressive type of brain tumor that arises from glial cells and is characterized by a specific mutation in the H3 histone gene, leading to various neurological symptoms.
H3 K27M-Mutant Diffuse Glioma: ONC201 Treatment Study
We are studying the effects of ONC201 in patients with H3 K27M-mutant diffuse glioma after radiotherapy. The goal is to see if it improves outcomes compared to a placebo.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 10 kg and 75 years old?
- Are you pregnant, breastfeeding, or planning to become pregnant while receiving study treatment?
- Do you have any known allergies to medications or treatments used in this study?
- Are you currently taking corticosteroids like Dexamethasone or Prednisone?
- Have you had any major surgery or treatment for cancer in the past 3 weeks?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Hexahydro-4-((2-Methylphenyl)methyl)-7-(phenylmethyl)imidazo(1,2-a)pyrido(3,4-e)pyrimidin-5(1h)-one
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
3be
Abidec Multivitamin
Activelle
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Medical University of Vienna
Department of Pediatrics and Adolescent Medicine
Vienna, Austria
Medical University of Vienna
Department of lnternal Medicine l, Division of Oncology
Vienna, Austria
Aalborg University Hospital
Department of Oncology
Aalborg, Denmark
Sponsor: Chimerix Inc.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.