Hairy Cell Leukemia: Vemurafenib and Rituximab Study

We are exploring a new treatment combination for hairy cell leukemia that may be less toxic than standard chemotherapy. This study aims to see if it is just as effective while monitoring patient safety and quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Mabthera
Mabthera is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting problematic immune cells.
Zelboraf
Zelboraf is a medicine used to treat melanoma (a type of skin cancer) that has spread and has a specific gene change.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cladribine
Cladribine is a substance that reduces specific immune cells to help control relapsing forms of multiple sclerosis.
Rituximab
Rituximab is a substance that targets and reduces B cells, a type of white blood cell, to treat some blood cancers and autoimmune conditions.
Vemurafenib
Vemurafenib is a substance that targets a specific BRAF mutation to slow growth of certain cancers, especially advanced melanoma.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Litak

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Blitzima
Ituxredi
Rixathon

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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University Of Bari Aldo Moro
UO Ematologia con Trapianto
Altamura, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi
SOD Clinica Ematologica
Ancona, Italy
Azienda Unita Sanitaria Locale Di Bologna
U.O. Ematologia, Istituto "L. e A. Seràgnoli”
Bologna, Italy

Sponsor: Universita' Degli Studi Di Perugia
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.