Head and Neck Cancer: Petosemtamab Treatment Study

We are studying the effects of petosemtamab in patients with advanced head and neck cancer who have not responded to previous treatments. The goal is to see if it improves survival and tumor response compared to standard therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Docetaxel Ever Valinject
Docetaxel Ever Valinject is a chemotherapy medicine used to treat various types of cancer.
Erbitux
Erbitux is a cancer treatment used to help slow the growth of certain colorectal and head and neck cancers.
Pemetrexed
Pemetrexed is a chemotherapy medicine used to treat certain types of lung cancer and mesothelioma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cetuximab
Cetuximab is a substance that targets a protein on cancer cells to help slow or stop growth in colorectal and head and neck cancers.
Docetaxel
Docetaxel is a chemotherapy substance used to treat various cancers by stopping cancer cells from dividing.
Methotrexate
Methotrexate is a substance that slows rapid cell growth and calms the immune system to treat certain cancers and autoimmune conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Methotrexate

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alimta
Armisarte
Bendadocel

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Katholieke Universiteit te Leuven
Medical Oncology
Heverlee, Belgium
Universitair Ziekenhuis Gent
Medical Oncology
Ledeberg, Belgium
Institut Jules Bordet
Oncology
Negenmanneke, Belgium

Sponsor: Merus N.V.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.