Heart Failure: Colchicine and Thiamine Study

We are studying whether colchicine and thiamine can help improve heart health in people with heart failure due to ischemic heart disease. The trial looks at their effects on serious heart-related events and hospital visits.

>2 years6-10 visitsConfirmation phase (III)Partially RemoteStandard MedicinesOralCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Benerva
Benerva is a medicine used to treat and prevent vitamin B1 deficiency and related nerve or brain problems.
Colchicina
Colchicina is a medicine used to treat and prevent gout attacks, relieving pain and swelling during flare-ups.
Colchicina Lirca
Colchicina Lirca is a medicine used to treat and prevent gout attacks.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Colchicine
Colchicine is a substance that reduces inflammation to treat and prevent gout attacks.
Thiamine Hydrochloride
Thiamine hydrochloride is a form of vitamin B1 used to prevent or treat deficiency and support nerve function and energy metabolism.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Apovit B1 Vitamin Ekstra Stærk
Betamine
Bevione

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliero Universitaria Delle Marche
SOD CARDIOLOGIA OSPEDALIERA E UTIC
Ancona, Italy
Azienda Sanitaria Locale Della Provincia Di Bari
CARDIOLOGIA-UTIC
Bari, Italy
ASST Grande Ospedale Metropolitano Niguarda
Cardiologia 2 - insufficienza cardiaca e trapianto
Bresso, Italy
Sponsor: Hamilton Health Sciences Corporation
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.