Chronic Systolic Heart Failure
Chronic systolic heart failure is a condition where the heart's left ventricle cannot pump blood effectively, leading to symptoms such as shortness of breath, fatigue, and fluid retention.
Heart Failure in Children: Vericiguat Study
We are studying a new medication, vericiguat, to see if it helps improve heart function in children with heart failure. The trial compares its effects to a placebo to ensure safety and effectiveness.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 3 kg and 18 years old?
- Do you have chronic heart failure (HF) with symptoms like shortness of breath or fatigue?
- Are you currently taking stable medications for heart failure?
- Are you pregnant or breastfeeding?
- Do you have severe kidney disease?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Mk-1242
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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UZ Leuven
Kindercardiologie
Heverlee, Belgium
Universitair Ziekenhuis Gent
Kindercardiologie
Ledeberg, Belgium
Centre Hospitalier Regional De La Citadelle
Cardiologie pédiatrique
Liège, Belgium
Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.