Heart Failure: Stopping Beta-Blockers

We are studying whether discontinuing beta-blockers is as safe for patients with improved heart function as continuing the medication. This trial aims to understand the effects on heart failure relapse and overall heart health.

>2 yearsConfirmation phase (III)Cost ReimbursementPartially RemoteInvestigational MedicinesOralCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carvedilol
Carvedilol is a medicine used to lower blood pressure and help treat heart failure by reducing the heart's workload.
Dapagliflozin
Dapagliflozin is a medicine that lowers blood sugar in adults with type 2 diabetes and can help protect the heart and kidneys.
Losartan
Losartan is a medicine used to lower high blood pressure and help protect the kidneys in some people with diabetes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carvedilol
Carvedilol is a substance that lowers blood pressure and heart workload by blocking heart and blood vessel receptors, used for heart failure and hypertension.
Dapagliflozin
Dapagliflozin is a substance that helps lower blood sugar in people with type 2 diabetes by causing the kidneys to remove excess glucose in urine.
Dapagliflozin Propanediol
Dapagliflozin propanediol is a substance that helps lower blood sugar in type 2 diabetes by helping the body remove glucose through urine.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ace Inhibitors

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acapril
Acarden
Accusol 35

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CHU De Martinique
Cardiologie
Amilly, France
Assistance Publique Hopitaux De Paris
Cardiologie
Angers, France
Centre Hospitalier Universitaire D'Angers
Cardiologie
Angers, France
Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.