Heart Failure Treatment: Sacubitril/Valsartan vs. Ramipril

We are studying how two heart medications affect heart function in patients with ischemic heart failure. Our goal is to see which treatment better helps improve heart structure and performance.

1-2 yearsConfirmation phase (III)Standard MedicinesOralCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ramipril
Ramipril is a medicine used to lower high blood pressure and reduce the risk of heart attack, stroke, and heart failure.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Hydrochlorothiazide
Hydrochlorothiazide is a substance that helps the body remove excess fluid to lower high blood pressure and reduce swelling.
Ramipril
Ramipril is a substance that helps lower high blood pressure and protect the heart by relaxing blood vessels.
Sacubitril
Sacubitril is a substance that helps improve heart function in people with heart failure by boosting natural heart-protective hormones.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acapril
Acovil
Alamut

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Krakowski Szpital Specjalistyczny Im. Sw. Jana Pawla II
Oddział Kliniczny Choroby Wieńcowej i Niewydolności Serca
Kraków, Poland
Uniwersytecki Szpital Kliniczny Im. Wojskowej Akademii Medycznej Uniwersytetu Medycznego W Lodzi Centralny Szpital Weteranow SPZOZ
Zakład Kardiologii Nieinwazyjnej
Łódź, Poland
Uniwersytecki Szpital Kliniczny W Opolu
Oddział Kardiologii
Opole, Poland
Sponsor: Krakowski Szpital Specjalistyczny Im. Sw. Jana Pawla II
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.