Heart Transplant in Children: Comparing Custodiol and Custodiol-N

We are studying the safety of two organ preservation solutions during heart transplants in children. This research aims to see which solution better supports recovery and overall health after surgery.

>2 years6-10 visitsEfficacy phase (II)No PlaceboPartially RemoteInvestigational MedicinesCardiologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Custodiol
Custodiol is a solution used to protect and preserve organs and heart tissue during transplant or cardiac surgery.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alanine
Alanine is an amino acid the body uses to build proteins and support energy production and blood sugar regulation.
Arginine
Arginine is an amino acid that helps the body produce nitric oxide to improve blood flow and support wound healing.
Aspartic Acid
Aspartic acid is an amino acid the body uses to build proteins and help metabolism and nerve signaling.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

4-Dimethoxy-N-Methyl-Benzamide
N-Hydroxy-3
N-Acetylhistidine

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Addex
Aminomel
Aminomix 1 Novum

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Charite Universitaetsmedizin Berlin KöR
Deutsches Herzzentrum der Charité
Berlin, Germany
Universitaetsklinikum Giessen und Marburg GmbH
Kinderherzzentrum
Gießen, Germany
Klinikum der Universitaet Muenchen AöR
Klinik und Poliklinik für Herzchirurgie
Neuried, Germany
Sponsor: Dr. Franz Koehler Chemie GmbH
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.