Hepatocellular Carcinoma: NMS-01940153E and Atezolizumab Study

We are studying a new treatment combination for adults with unresectable hepatocellular carcinoma who have been treated with other anti-cancer medicines. The goal is to see how well this combination works and its safety compared to existing options.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dacogen
Dacogen is a chemotherapy medicine used to treat certain blood cancers and bone marrow disorders, including some types of leukemia.
Tecentriq
Tecentriq is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Atezolizumab
Atezolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-L1.
Decitabine
Decitabine is a substance used to treat certain blood cancers by helping abnormal bone marrow cells stop growing and die.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Nms-01940153E
Dihydro Pyrazoloquinazoline Carboxamide Phosphate
N-(2,6-Diethylphenyl)-8-({4-[4-(Dimethylamino)piperidin-1-yl]-2-Methoxyphenyl}amino)-1-Methyl-4

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Inaqovi

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fondazione IRCCS Istituto Nazionale Dei Tumori
Medical Oncology
Milan, Italy
Istituto Oncologico Veneto
Oncology
Padova, Italy
Humanitas Mirasole S.p.A.
Medical Oncology and Hematology Unit
Rozzano, Italy

Sponsor: Nerviano Medical Sciences S.r.l.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.