HER2+ Breast Cancer: Tucatinib with Oral Etoposide and Trastuzumab

We are studying a new treatment combining tucatinib, oral etoposide, and trastuzumab for patients with metastatic HER2+ breast cancer who have not responded to prior therapies. The goal is to see if this combination improves treatment outcomes and safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Herceptin
Herceptin is a medicine used to treat certain types of breast and stomach cancer.
Tukysa
Tukysa is a cancer medicine used to treat a specific kind of breast cancer that grows because of a protein called HER2.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Etoposide
Etoposide is a substance used to treat certain cancers by stopping fast-growing cancer cells from dividing.
Trastuzumab
Trastuzumab is a substance that targets HER2 proteins to treat certain HER2-positive breast and stomach cancers.
Tucatinib
Tucatinib is a substance that blocks the HER2 protein to help treat HER2-positive breast cancer.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Celltop

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Herwenda
Herzuma
Kadcyla

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut Sainte Catherine
Oncologie Médicale
Avignon, France
Centre Francois Baclesse
Pathologie mammaire
Caen, France
Institut Regional Du Cancer De Montpellier
Oncologie médicale
Grabels, France

Sponsor: Institut Curie
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.