HER2+ Metastatic Colorectal Cancer: Tucatinib Combination Study

We are investigating whether a new treatment combining tucatinib, trastuzumab, and mFOLFOX6 can improve outcomes for patients with HER2+ metastatic colorectal cancer compared to standard care.

>2 years ≤5 visits Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Standard Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Avastin

Avastin is a cancer medicine used to slow tumor growth by stopping tumors from getting new blood vessels.

Erbitux

Erbitux is a cancer treatment used to help slow the growth of certain colorectal and head and neck cancers.

Herceptin

Herceptin is a medicine used to treat certain types of breast and stomach cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bevacizumab

Bevacizumab is a substance that blocks formation of new blood vessels to treat certain cancers and eye conditions caused by abnormal vessel growth.

Cetuximab

Cetuximab is a substance that targets a protein on cancer cells to help slow or stop growth in colorectal and head and neck cancers.

Trastuzumab

Trastuzumab is a substance that targets HER2 proteins to treat certain HER2-positive breast and stomach cancers.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abevmy

Alymsys

Avzivi

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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SCRI CCCIT Ges.m.b.H.

Univ. Klinik für Innere Medizin III der PMU

Salzburg, Austria

Medical University Of Vienna

Universitätsklinik für Innere Medizin I, Klinische Abteilung für Onkologie

Vienna, Austria

Klinikum Wels-Grieskirchen GmbH

Abteilung für Innere Medizin IV

Wels, Austria

Sponsor: Seagen Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.