HER2-Positive Biliary Tract Cancer: GemCis with Trastuzumab and Pembrolizumab

We are studying a combination of treatments for people with HER2-positive biliary tract cancer to see if it improves response rates and overall survival. This trial aims to assess both the effectiveness and safety of the treatment.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cisplatin Teva
Cisplatin Teva is a chemotherapy medicine used to treat various types of cancer.
Gemcitabin Gry
Gemcitabin Gry is a chemotherapy medicine used to treat various types of cancer, such as pancreatic, lung, and bladder cancer.
Herceptin
Herceptin is a medicine used to treat certain types of breast and stomach cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cisplatin
Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.
Gemcitabine Hydrochloride
Gemcitabine hydrochloride is a chemotherapy substance used to treat several types of cancer by interfering with cancer cell growth and division.
Pembrolizumab
Pembrolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-1.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bendacitabin
Cisplatin
Cisplatin "ebewe"

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Charite Universitaetsmedizin Berlin KöR
Med. Klinik für Hämatologie und Onkologie
Berlin, Germany
Universitaetsklinikum Duesseldorf AöR
Klinik für Gastroenterologie, Hepatologie und Infektiologie
Düsseldorf, Germany
Krankenhaus Nordwest GmbH
Institut für Klinisch-Onkologische Forschung
Eschborn, Germany

Sponsor: Institut fuer Klinische Krebsforschung IKF GmbH
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.