HER2-positive Breast Cancer: Trastuzumab Deruxtecan Study

We are comparing a new treatment with standard therapy for patients with HER2-positive breast cancer. The goal is to see which approach leads to better outcomes and to understand the effects on quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Betapred
Betapred is a medicine used to reduce inflammation, treat allergic reactions, and manage certain immune-related conditions.
Carboplatin Accord
Carboplatin Accord is a chemotherapy medicine used to treat several types of cancer.
Dexamethasone Orifarm
Dexamethasone Orifarm is a steroid medicine used to reduce inflammation and treat severe allergic and immune-related conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Aprepitant
Aprepitant is a substance that prevents nausea and vomiting by blocking a brain receptor, often used with chemotherapy or after surgery.
Betamethasone
Betamethasone is a corticosteroid substance that reduces inflammation and suppresses immune responses for conditions like eczema, allergies, and arthritis.
Betamethasone Sodium Phosphate
Betamethasone sodium phosphate is a corticosteroid substance that reduces inflammation and suppresses immune reactions in allergic, inflammatory, and skin conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Goserelin
Perjeta
Emend

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax
Aedon
Aeroflat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ziekenhuis Aan De Stroom
Medical Oncology
Berchem, Belgium
UZ Leuven
General Oncology
Heverlee, Belgium
Institut Jules Bordet
Medical Oncology
Negenmanneke, Belgium

Sponsor: Karolinska University Hospital
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.