HER2-Positive Breast Cancer: Zanidatamab vs. Trastuzumab

We are studying whether zanidatamab combined with chemotherapy is more effective and safer than trastuzumab with chemotherapy for patients with metastatic HER2-positive breast cancer who have not responded to previous treatments.

3-6 months Confirmation phase (III)No Placebo Cost Reimbursement Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Capecitabine

Capecitabine is a chemotherapy medicine used to treat certain cancers, including breast and colon cancer.

Eribulin

Eribulin is a chemotherapy medicine used to treat certain advanced or spreading cancers, including some types of breast and soft-tissue cancer.

Herceptin

Herceptin is a medicine used to treat certain types of breast and stomach cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Capecitabine

Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.

Eribulin

Eribulin is a substance that treats certain cancers by stopping cancer cells from dividing.

Eribulin Mesylate

Eribulin mesylate is a cancer treatment substance used to treat certain advanced breast cancers and soft tissue sarcomas.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Jzp598

Zanidatamab

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Advz

Capecel

Capecitabin Al

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck

Universitaetsklinik fuer Frauenheilkunde, Abteilung Gynaekologie und Geburtshilfe

Innsbruck, Austria

Ordensklinikum Linz GmbH

Interne I: Medizinische Onkologie und Hämatologie

Linz, Austria

Medical University Of Vienna

Universitätsklinik f. Innere Medizin I, Klinische Abteilung für Onkologie

Vienna, Austria

Sponsor: Jazz Pharmaceuticals Ireland Limited

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.