HER2 Positive Esophageal Cancer: HERES Trial

We are studying whether adding trastuzumab to standard chemotherapy and immunotherapy helps patients with HER2 positive esophageal squamous cell carcinoma live longer without disease progression.

>2 years6-10 visitsEfficacy phase (II)No PlaceboStandard MedicinesOralInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Capecitabine
Capecitabine is a chemotherapy medicine used to treat certain cancers, including breast and colon cancer.
Herceptin
Herceptin is a medicine used to treat certain types of breast and stomach cancer.
Trazimera
Trazimera is a cancer medicine used to treat certain breast and stomach cancers that have high levels of a growth-promoting protein.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Capecitabine
Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.
Fluorouracil
Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.
Oxaliplatin
Oxaliplatin is a substance used in chemotherapy to treat colorectal and other cancers by killing cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Capecel
Capecitabin Al
Capecitabin Amarox

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Aalborg University Hospital
Department of Oncology
Aalborg, Denmark
Rigshospitalet
Department of Oncology
Copenhagen, Denmark
Odense University Hospital
Department of Oncology
Odense, Denmark
Sponsor: Rigshospitalet
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.