HER2-Positive Gastric Cancer: Trastuzumab Deruxtecan Study

We are testing a new treatment combining Trastuzumab Deruxtecan with chemotherapy for patients with advanced HER2-positive gastric or GEJ cancer. The goal is to see if this combination works better than the current standard treatment.

>2 years 6-10 visits Confirmation phase (III)No Placebo Cost Reimbursement Investigational Medicines Oral InjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Capecitabine

Capecitabine is a chemotherapy medicine used to treat certain cancers, including breast and colon cancer.

Cisplatin Hikma

Cisplatin Hikma is a chemotherapy medicine used to treat various types of cancer.

Herceptin

Herceptin is a medicine used to treat certain types of breast and stomach cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Capecitabine

Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.

Cisplatin

Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.

Fluorouracil

Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ds-8201a

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Capecel

Capecitabin Al

Capecitabin Amarox

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz

Department of Oncology

Graz, Austria

Medizinische Universitaet Innsbruck

Department of Internal Medicine V

Innsbruck, Austria

St. Josef Krankenhaus GmbH

Internal Medicine Department I and II

Perchtoldsdorf, Austria

Sponsor: Daiichi Sankyo Inc.

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.