Hereditary Angioedema: PHA-022121 Treatment Study

We are testing the safety of a new oral medication for treating acute angioedema attacks in patients with hereditary angioedema. The study will also evaluate how well it relieves symptoms during these attacks.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Icatibant
Icatibant is a medicine used to treat sudden, painful swelling attacks in people with hereditary angioedema.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Deucravacitinib
Deucravacitinib is a substance that blocks a specific immune enzyme to lower inflammation, mainly used for moderate-to-severe plaque psoriasis.
Icatibant
Icatibant is a substance that quickly reduces sudden, severe swelling attacks in people with hereditary angioedema by blocking the swelling process.
Icatibant Acetate
Icatibant acetate is a substance that quickly reduces sudden swelling in hereditary angioedema by blocking the natural chemical that causes swelling.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Pha-022121
Deucrictibant

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Firazyr
Icatibant "viatris"
Icatibant Accord

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Department of Dermatology and Venereology
Graz, Austria
Johannes Kepler University Linz
Department of Dermatology and Venereology
Linz, Austria
Universitaet Wien
Department of Dermatology
Vienna, Austria

Sponsor: Pharvaris Netherlands B.V.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.