High-Risk Myelodysplastic Syndromes: Stem Cell Transplantation Study

We are evaluating a new treatment approach that combines hypomethylating therapy with stem cell transplantation for patients with high-risk myelodysplastic syndromes. The study aims to assess the feasibility and safety of this combined treatment.

6-10 visitsConfirmation phase (III)No PlaceboStandard MedicinesInjectionHematology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Azacitidine Accord
Azacitidine Accord is a medicine used to treat certain bone marrow disorders and some types of blood cancer.
Cytarabine
Thiotepa
Thiotepa is a chemotherapy medicine used to treat certain cancers and sometimes given before bone marrow transplant.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Azacitidine
Azacitidine is a substance that treats certain bone marrow disorders and blood cancers by slowing abnormal blood cell growth and restoring healthier blood production.
Busulfan
Busulfan is a substance used to destroy bone marrow cells before a bone marrow transplant and to treat certain blood cancers.
Cytarabine
Cytarabine is a chemotherapy substance used to treat certain blood cancers, especially acute leukemias.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alexan
Ara-Cell
Aracytin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliero-Universitaria Ss Antonio E Biagio E Cesare Arrigo
DIPARTIMENTO INTERNISTICO E DI EMERGENZA-URGENZA E ACCETTAZIONE STRUTTURALE - SCDU EMATOLOGIA
Alessandria, Italy
University Hospital Consorziale Policlinico
DIPARTIMENTO DELL'EMERGENZA E DEI TRAPIANTI DI ORGANI (D.E.T.O.) - UO EMATOLOGIA CON TRAPIANTO
Altamura, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi
DIPARTIMENTO DI MEDICINA INTERNA - SOD CLINICA EMATOLOGICA
Ancona, Italy
Sponsor: Fondazione Gimema Franco Mandelli Onlus
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.