High-Risk Prostate Cancer: THUNDER Trial

We are studying new diagnostic tracers and treatment options for men with high-risk prostate cancer. The goal is to see if these methods improve survival and quality of life compared to standard treatments.

1-2 years6-10 visitsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesOralInjectionOncologyUrology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Decapeptyl Sustained Release
Decapeptyl Sustained Release is a medicine used to reduce sex hormone activity for treating prostate cancer, endometriosis, and other hormone-related conditions.
Degarelix Accord
Degarelix Accord is a medicine used to treat advanced prostate cancer by quickly lowering male hormone levels.
Depo-Eligard
Depo-Eligard is an injectable medicine that lowers male hormone levels to help treat prostate cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Darolutamide
Darolutamide is a substance that blocks male hormones' effects to help treat prostate cancer.
Degarelix
Degarelix is a substance that rapidly lowers testosterone to help control advanced prostate cancer.
Docetaxel
Docetaxel is a chemotherapy substance used to treat various cancers by stopping cancer cells from dividing.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Bay 1841788

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Algonad
Algonad
Arvekap

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Onze-Lieve-Vrouwziekenhuis
Radiotherapy
Aalst, Belgium
Ziekenhuis Aan De Stroom
Radiotherapy
Berchem, Belgium
CHU Helora
Oncology
Fayt-lez-Manage, Belgium
Sponsor: Ziekenhuis Aan De Stroom
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.