Erdheim-Chester Disease
Erdheim-Chester Disease is a rare form of histiocytosis characterized by the abnormal proliferation of histiocytes, leading to various symptoms including bone pain, skin lesions, and organ dysfunction.
Histiocytosis in Children: Trametinib Study
We are testing the safety and effectiveness of trametinib in children with refractory histiocytosis. The goal is to find the best dosage and timing for treatment after other therapies have failed.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Rosai-Dorfman Syndrome
Rosai-Dorfman Syndrome is a rare disorder characterized by the overproduction of histiocytes, often leading to swollen lymph nodes, fever, and weight loss.
Langerhans' Cell Histiocytosis
Langerhans' Cell Histiocytosis is a rare disease where Langerhans cells proliferate abnormally, potentially affecting the skin, bones, and organs, leading to various symptoms.
Langerhans Cell Sarcoma
Langerhans Cell Sarcoma is a rare and aggressive tumor arising from Langerhans cells, which can present with symptoms such as pain, swelling, and systemic symptoms.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you pregnant or breastfeeding?
- Do you have any allergies to medications, especially Trametinib?
- Have you been diagnosed with any other cancers before this study?
- Are you currently taking any medications that might interact with Trametinib?
- Have you had any serious eye problems like iritis or uveitis?
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Instytut Matki I Dziecka
Department of Oncology and Oncological Surgery for Children and Adolescents
Wola, Poland
Sponsor: Instytut Matki I Dziecka
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.