HIV-1 Prevention: MK-8527 Oral Medication

We are studying a new once-monthly pill, MK-8527, to see if it can effectively prevent HIV-1 infection compared to a daily treatment. The trial will also assess how safe and tolerable this new medication is for participants.

>2 years>20 visitsConfirmation phase (III)Post-Trial Drug AccessPartially RemoteInvestigational MedicinesOralInfectious DiseasesInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Emtricitabine
Emtricitabine is a substance that helps prevent and treat HIV by stopping the virus from multiplying when used with other HIV treatments.
Tenofovir
Tenofovir is a substance that helps control HIV and chronic hepatitis B by lowering the amount of virus in the body.
Tenofovir Disoproxil
Tenofovir disoproxil is a substance that helps stop certain viruses (including HIV and hepatitis B) from multiplying in the body.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mk-8527
Emtricitabine/Tenofovir Disoproxil

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Assistance Publique Hopitaux De Paris
Service des Maladies Infectieuses
Bagnolet, France
Assistance Publique Hopitaux De Paris
Service des Maladies Infectieuses et Tropicales
Quinze-Vingts, France
Assistance Publique Hopitaux De Paris
Service des Maladies Infectieuses et Tropicales
Saint-Ouen, France
Sponsor: Merck Sharp & Dohme LLC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.