Hodgkin Lymphoma: Ruxolitinib with Brentuximab or Pembrolizumab

We are studying the combination of ruxolitinib with either brentuximab or pembrolizumab for patients with relapsed or refractory classical Hodgkin lymphoma. The goal is to see if this combination improves treatment response and safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Adcetris
Adcetris is a cancer medicine used to treat certain types of lymphoma, cancers that affect the lymphatic (immune) system.
Jakavi
Jakavi is a medicine used to treat certain serious blood disorders that affect bone marrow and blood cell production.
Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Brentuximab Vedotin
Brentuximab vedotin is a substance used to treat certain types of lymphoma by targeting cancer cells with the CD30 protein.
Pembrolizumab
Pembrolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-1.
Ruxolitinib
Ruxolitinib is a substance that blocks cell signals to reduce abnormal blood cell growth and inflammation in certain bone marrow disorders.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Opzelura

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Unita Sanitaria Locale Di Bologna
U.O. Ematologia, Istituto "L. e A. Seràgnoli"
Bologna, Italy
Istituto Nazionale Dei Tumori
S.C. Ematologia
Milan, Italy
Istituto Europeo Di Oncologia S.r.l.
Divisione di Oncoematologia
Opera, Italy

Sponsor: Universita' Degli Studi Di Perugia
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.