Hormonal Treatment for Adolescents with Gender Dysphoria

We are studying the effects of starting hormonal treatment at age 14 on the well-being of adolescents with gender dysphoria. This research aims to assess both the effectiveness and safety of the treatment as they transition into adulthood.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Androgel
AndroGel is a prescription skin gel that replaces testosterone in men with low levels to help reduce symptoms like fatigue and low sex drive.
Estreva
Estreva is a vaginal estrogen cream used to relieve menopausal vaginal dryness and discomfort.
Provames

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Estradiol Hemihydrate
Estradiol hemihydrate is a form of the female hormone estrogen used to replace low estrogen and relieve menopausal symptoms.
Testosterone
Testosterone is a hormone substance used to replace low male sex hormones and help restore energy, libido, and muscle strength.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Androtop
Dermestril 25
Dermestril 25

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Assistance Publique Hopitaux De Paris
Service Endocrinologie et Diabète de l'enfant
Croulebarbe, France
Assistance Publique Hopitaux De Paris
Pediatric Endocrinology Department
Le Pré-Saint-Gervais, France
Assistance Publique Hopitaux De Paris
Child and Adolescent Psychiatry
Le Pré-Saint-Gervais, France

Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.