HPV-Negative Head and Neck Cancer: PARP Inhibitor and Immunotherapy Study

We are investigating a new treatment combining a PARP inhibitor and immunotherapy for patients with HPV-negative head and neck cancer. The study aims to see how well this treatment works and its safety compared to standard options.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Zejula
Zejula is a cancer medicine used to help prevent recurrence of ovarian, fallopian tube, or primary peritoneal cancer after chemotherapy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dostarlimab
Dostarlimab is a monoclonal antibody that helps the immune system attack certain cancers by blocking a protein that restrains immune response.
Niraparib
Niraparib is a substance used to treat certain cancers by blocking cancer cells' ability to repair DNA, helping prevent tumors from returning.
Niraparib Tosilate Monohydrate
Niraparib tosilate monohydrate is a substance that helps treat certain cancers by blocking cancer cells' ability to repair damaged DNA.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Jemperli

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
Medical Oncology
Brescia, Italy
IRCCS Ospedale Policlinico San Martino
Oncologia Medica 2
Genoa, Italy
Azienda Ospedaliero-Universitaria Maggiore Della Carita
SCDU Oncologia
Novara, Italy

Sponsor: Gruppo Oncologico Del Nord Ovest
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.