Hydrochlorothiazide for Polycystic Kidney Disease Patients

We are studying whether adding hydrochlorothiazide to tolvaptan can help slow kidney function decline in people with polycystic kidney disease. This trial also looks at how this combination affects quality of life and treatment tolerability.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Jinarc
Jinarc is a medicine used to slow the progression of polycystic kidney disease, a hereditary condition that causes many fluid-filled cysts in the kidneys.
Tolvaptan
Tolvaptan is a medicine that helps the body get rid of excess water to treat low blood sodium and certain kidney conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Hydrochlorothiazide
Hydrochlorothiazide is a substance that helps the body remove excess fluid to lower high blood pressure and reduce swelling.
Tolvaptan
Tolvaptan is a substance that raises low blood sodium and can slow kidney function decline in people with certain polycystic kidney disease.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Gurdatol
Gurdatol
Samsca

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven
Department of Nephrology
Heverlee, Belgium
Cliniques Universitaires Saint-Luc
Department of Nephrology
Sint-Stevens-Woluwe, Belgium
Centre Hospitalier Regional Et Universitaire De Brest
Department of Nephrology
Guilers, France

Sponsor: University Medical Center Groningen
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.